She has vast experience in the Development field. She worked for a time with the Jesuit Refugee Service (JRS) in Zambia, and was Education Co-ordinator at the Meheba Refugee Settlement in Solwezi. This grew out of a refugee camp for Angolans fleeing war in their own country. She later became director of the programme there for JRS.
From 2008 to 2013, Sr. Kayula worked with the Jesuit Centre for Theological Reflection (JCTR) in Lusaka, a research, education and advocacy Centre that promotes study and action on various development issues linking Christian Faith and Social Justice in Zambia and Malawi. The Centre also strives to create a value base for public policy.
While at JCTR, she was a member of the African Forum for Church Social Teaching (AFCAST) and of an Access to Information Task Force established in 2012 by the then Zambian President to draft an Access to Information Bill.
Sr. Kayula currently manages Dialogue for Development (D4D), a Peace building Programme under the Religious Sisters of Charity Zambia/Malawi Region, which facilitates dialogue on human rights issues such as human trafficking and child protection and promotes active citizenship with special reference to the care of the Earth.
In 2018, Pope Francis appointed Sr. Kayula for a second term to the Pontifcal Commission for the Protection of Minors.